The present review aim to help scientific community to better understand, in vitro and in vivo, COVID-19 compared to Monge disease (MD). The SARS-COV-2 or Corona-nanoparticles (NPs: 60-140nm) model based on nanosciences give an innovative understanding of virus nanotoxicity associated to violent inflammatory reactions and acute respiratory distress. Our analysis of COVID-19 suggest for the first time as far as we know that SARS-COV-2 use nanosciences laws such as virus agglomeration and mitochondria respiration toxicity induced by cluster virus-Heme. Moreover, the implication of age, gender, and ethnicity to COVID-19 must be confirmed by future studies compared to MD. Virus could use nanomechanisms to induce hypoxia via generation of Heme-virus clusters mitigating microcoagulation implicated in acute respiratory distress and heart failure. Our analysis point to the presence of possible link between hypoxia and COVID-19 pro-pulmonary complications.

Introduction: Pleuropulmonary with bony and cutaneous involvement of salmonella infection is a very rare condition and no case was ever reported in Lebanon. Case presentation: We report a case of 39-year-old immunocompetent man, with no past medical history, presented with a right bulging chest wall mass. The chest radiographs revealed pleural effusion and presence of a hypodense central necrosis at right lower lung field. Salmonella was identified from the cultures of fine needle aspiration (FNA) form the mass. After treating salmonella with adequate antibiotics, the patient was improved. Discussion: salmonella infection is a common bacterial disease that affects the intestinal tract. Infection may spread beyond the intestine causing many complications like in our reported case. Conclusion: we should suspect salmonellosis in any patient presenting with gastrointestinal symptoms followed by pleuropneumonia with chest wall infection.

Targeted Temperature Management has been the standard of care in post cardiac arrest since 2005. Despite significant advancements since its infancy, and a multitude of studies, discrepancies still exist as to its efficacy. By understanding the associated adverse effects, we can begin to delineate incongruencies to guide future research in order to progress towards a more uniform “high-quality” Targeted Temperature Management. Both anticonvulsant and antiarrhythmic therapy may provide an avenue towards improving Targeted Temperature Management.

Background: In this study, we indicate the importance of a case, where specific diagnostic tests such as NK level, NK endometrial cells, NK activity, embryotoxicity (ETA), and PLA (platelet leukocyte aggregates) were used for investigating infertile women with many failed IVFs. Case presentation: We describe a very important case of unexplained infertility, where a 46 year old lady managed finally to get pregnant after 12 years of consecutive trials and 10 failed IVFs. Our center tested her for all 3 NK markers, ETA, and Vitamin D3, TSH, and PLA, which are essential for positive pregnancy. The lady was treated with intravenous solution of intralipid after the high NK result. She was administered with two dosages and then performed embryo transfer where after 10 days she received the positive pregnancy test result. Conclusion: The high evaluation of immune status based on the specific tests of NK panel (all 3 markers), ETA, and PLA can save time and money for couples that have attempted several embryo transfers in IVF centers with unsuccessful pregnancies. Also, the targeted individualized treatment of the couple can significantly increase the chances for successful pregnancy.

In recent years, an important part of the ionizing radiation (IR) that human have been exposed for diagnostic purposes are interventional radiologic procedures. The X-rays and contrast media are used in angiography. The patients and staff members are exposed to X-ray during these procedures. While it is known that X-rays cause DNA damage and carcinogenesis, the effect of the contrast agent is still unknown. The aim of this study was to investigate the effect of X-rays and contrast agent on chromosomes of human patients. Peripheral blood samples were taken from 50 patients (30 males, 20 females, ages between 38-75 years). Chromosome analysis of peripheral lymphocytes in 50 patients were performed at 3 different periods; before the interventional radiologic procedure, 24 hours and 1-3 months after the procedure. Also, chromosome analysis was performed on 17 staff members working during interventional radiological procedures to investigate the effect of X-rays. Standard cytogenetic analysis techniques were used for this study. The frequency of chromosomal aberrations (CAs) was significantly higher in patients 24 hours after the interventional radiologic procedures than pretreatment (p=0,000). At the same time, CAs after 24 hours compared with those taken 1-3 months later, shown that the CAs were significantly reduced after 1-3 months (p=0,000). We also found that the frequency of CAs was also statistically higher in patients exposed to high radiation doses (p=0,042). Compared with the control group (n=30), CAs were found significantly higher in workers exposed to radiation. Our findings have shown that X-rays and contrast agents that used in interventional radiological cause chromosomal damage. For this reason, the dose of radiation to be given to the patient must be carefully selected. Due to the potentially high genetic damage of patients with coronary artery disease (CAD), the type and amount of medication to be given and the frequency of radiological diagnostic procedures to be performed should be meticulously adjusted.